Appetite-suppression

Amphetamines including lisdexamfetamine (Vyvanse/Elvanse) and mixed amphetamine salts suppress appetite through dopaminergic and noradrenergic mechanisms. This article reviews the pharmacology, the clinical evidence on weight effects, the distinction between ADHD treatment and weight management use, and the evidence-based alternatives.

The 'coffee method' refers to using caffeine's thermogenic and appetite-suppressing properties to support weight loss. Caffeine increases energy expenditure by 8–11% acutely, suppresses appetite modestly, and enhances exercise performance. The evidence is real but modest — and tolerance limits chronic effects.