Weight-loss-medication

Oprah Winfrey's public disclosure of using weight loss medication brought GLP-1 receptor agonists into mainstream conversation. This article examines what the clinical evidence shows about these medications, who qualifies for them, and what realistic expectations look like.

Four weight loss medications are licensed in the UK: orlistat (NHS Tier 2), liraglutide/Saxenda (NHS Tier 3), semaglutide/Wegovy (NHS Tier 3), and tirzepatide/Mounjaro (NHS Tier 3). Phentermine is not licensed in the UK. This article covers mechanisms, evidence, NHS eligibility, and the private prescribing pathway.