Prediabetes

Weight loss is the most powerful non-pharmacological intervention for lowering A1C — with clinical trials showing potential for full type 2 diabetes remission. Here is the quantitative evidence and mechanisms behind the relationship.

Insulin resistance is associated with weight gain and is highly prevalent in people with obesity (approximately 50–80%). However, it is primarily a consequence of excess adiposity rather than an independent cause of weight loss difficulty. Diet and exercise that produce modest weight loss (5–10%) improve insulin sensitivity substantially — regardless of which dietary approach achieves the loss. NICE recommends the NHS Diabetes Prevention Programme (NDPP) for non-diabetic hyperglycaemia.