Three injectable weight loss medications are licensed in the UK: liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Mounjaro). Head-to-head trial data shows tirzepatide produces the greatest weight loss (~20.9%), followed by semaglutide (~14.9%), then liraglutide (~8.4%). This article compares them across efficacy, side effects, dose schedule, and UK licensing.