Calorie targets for weight loss require calculating TDEE using Mifflin-St Jeor (most validated equation), then applying a deficit of 500–750 kcal/day for NICE-recommended 0.5–1 kg/week loss. Minimum safe intakes: 1,200 kcal/day (women), 1,500 kcal/day (men) without supervision. Metabolic adaptation (Leibel 1995: −250 kcal/day after 10% loss) requires recalculation every 5–10 kg. This article provides the calculation framework and worked examples.