Zoloft (sertraline) can affect weight in complex ways. This article explains the mechanism, what research says about weight changes on SSRIs, and evidence-based strategies for managing your weight while taking sertraline.
Sertraline (Zoloft) has a more complex relationship with weight than most people realise. Short-term weight loss is common early on; longer-term weight gain is more common with sustained use. Here is what the evidence shows and practical strategies for managing weight while on SSRIs.