Published onJanuary 23, 2025Losing Weight While on Zoloft: Understanding the Connection and Finding Solutionsweight-losszoloftsertralineantidepressantsmetabolismSSRIhealthZoloft (sertraline) can affect weight in complex ways. This article explains the mechanism, what research says about weight changes on SSRIs, and evidence-based strategies for managing your weight while taking sertraline.