Rapid weight loss produces specific physiological consequences beyond simple fat reduction: lean mass loss, metabolic rate suppression, gallstone formation, nutrient deficiencies, and psychological rebound. This article reviews the evidence behind each risk and what rate of loss minimises them.
Weight loss is harder than a simple calorie arithmetic model predicts because the body actively defends fat stores through hormonal and neurological adaptation. This article reviews the biological mechanisms that make weight loss difficult and what evidence-based approaches can overcome them.
Self-reported calorie intake in research underestimates actual intake by 20–40% on average. If you are 'in a deficit' but not losing weight, the most likely explanation is that the deficit is smaller than believed. This article explains the measurement errors and how to correct them.
Weight loss plateaus on Ozempic (semaglutide) occur through specific, identifiable mechanisms — under-dose, metabolic adaptation, calorie compensation, and lean mass loss. This article covers each cause with clinical evidence and evidence-based responses.