Cancer

Even modest weight loss — 5–10% of body weight — produces measurable clinical benefits across multiple disease categories. This article reviews the evidence on weight loss benefits for cardiovascular, metabolic, musculoskeletal, and oncological health.

Unintentional weight loss exceeding 5% of body weight over 6–12 months, or any unexplained rapid loss, requires medical investigation. Common causes include hyperthyroidism, type 2 diabetes, coeliac disease, IBD, depression, and malignancy. NICE guidelines define the investigation pathway. This article covers what to look for and when to contact a GP.

Losing weight without trying — particularly 5% or more body weight in 6 months — is a clinical red flag requiring GP assessment. Cancer is one of multiple possible causes. This article covers what weight of loss is medically significant, the full differential diagnosis, when to seek urgent versus routine care, and what investigations to expect.

Unexplained weight loss can be a concerning symptom. This article explores the link between weight loss and cancer, explaining the underlying mechanisms and when to seek medical advice.